| Customization: | Available |
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| Varieties: | General Disease Prevention Medicine |
| Component: | Chemical Synthetic Drugs |
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This product is produced in strict accordance with GMP organization and in line with quality standards
| Product name | Amikacin |
| Physical and Chemical Properties | This product is a semi synthetic aminoglycoside drug derived from kanamycin. Its sulfate is a white or almost white crystalline powder, which is highly soluble in water. The pH value of a 1% aqueous solution is 6-7.5. |
| Function and Use | This product has a similar antibacterial spectrum to gentamicin and is mainly used for infections caused by gram-negative bacteria resistant to gentamicin or kanamycin, especially Pseudomonas aeruginosa in the urinary tract, lower respiratory tract, abdominal cavity, reproductive system, etc., such as Pseudomonas aeruginosa in chickens and cats. This product belongs to bactericidal antibiotics, and alkaline environments can enhance its antibacterial activity. It may inhibit the protein synthesis of sensitive bacteria by irreversibly binding to the 30s subunit of ribosomes. The absorption of this product is poor when taken orally or administered intrauterine, but it can be absorbed when administered through local irrigation during surgical procedures (not on the skin or bladder). Oral administration of amikacin can also be well absorbed in animals with hemorrhagic or necrotizing enteritis. After intramuscular injection in dogs and cats, there was a blood drug peak at 0.5-1 hour, and the peak time of subcutaneous injection was slightly delayed, with greater individual differences than intramuscular injection. The bioavailability of extravascular injection (intramuscular or subcutaneous injection) is greater than 90%. |
| Usage and Dosage | After absorption, this product is mainly distributed in extracellular fluid, which can be seen in ascites, pleural fluid, pericardial fluid, synovial fluid, and pus, and has high concentrations in saliva, bronchial secretions, and bile. The binding rate between this product and plasma proteins is relatively low (less than 20%), making it difficult to pass through the blood-brain barrier and unable to enter eye tissue. After injection, therapeutic concentrations can be reached in bone, heart, gallbladder, and lung tissues. This product can accumulate in certain tissues, such as the inner ear and kidneys, which helps explain its toxicity. It can also pass through the placenta, causing the fetal serum concentration to be 15% to 50% of that of the mother. |
| Storage | Stored under shade and sealed |
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